PNU-101603

Names

[ Name ]:
PNU-101603

[Synonym ]:
N-({(5S)-3-[3-Fluoro-4-(1-oxido-4-thiomorpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide
Acetamide, N-[[(5S)-3-[3-fluoro-4-(1-oxido-4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-
N-({(5S)-3-[3-fluoro-4-(1-oxidothiomorpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide

Biological Activity

[Description]:

PNU-101603 is a metabolite of Sutezolid (HY-10392). PNU-101603 has excellent activity against Mycobacterium tuberculosis (MTB)[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

PNU-101603 (compound 7, 21 days) inhibits M. tuberculosis activity[2]. Cell Viability Assay[2] Cell Line: M. tuberculosis Concentration: 0-1 μg/mL approximately Incubation Time: 21 days Result: Inhibited M. tuberculosis with a MIC value ≤0.125 μg/mL.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
698.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₂₀FN₃O₄S

[ Molecular Weight ]:
369.411

[ Flash Point ]:
376.4±31.5 °C

[ Exact Mass ]:
369.115845

[ LogP ]:
-1.20

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.645

Related Compounds

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