SRI-011381
Names
Biological Activity
[Description]:
SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2].
[Related Catalog]:
[In Vitro]
SRI-011381 (10 μM) promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression[1].
[In Vivo]
SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice[2]. Animal Model: YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)[2] Dosage: 30 mg/kg Administration: Intraperitoneally injection; every 2 d; for 22 days Result: Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C20H31N3O
[ Molecular Weight ]:
329.48