SRI-41315
Names
[ CAS No. ]:
1613509-49-1
[ Name ]:
SRI-41315
Biological Activity
[Description]:
SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion, restores CFTR expression and function, suppresses CFTR nonsense mutations.SRI-41315 induces translational readthrough by depleting eRF1 protein level and prolonging the translational pause that occurs at premature termination codons (PTCs).SRI-41315 reduced eRF1 levels in a manner dependent upon a ubiquitin-mediated proteasome degradation pathway.SRI-41315 in combination with G418 restores CFTR function in primary bronchial epithelial cells derived from a CF patient with CFTR nonsense alleles.
[References]
1. Sharma J, et al. Nat Commun. 2021 Jul 16;12(1):4358.
Chemical & Physical Properties
[ Molecular Formula ]:
C22H19N3O2
[ Molecular Weight ]:
357.413