NSC363998 free base

Names

[ Name ]:
NSC363998 free base

Biological Activity

[Description]:

NSC363998 (free base) is an orally active compound. NSC363998 (free base) can suppress rCGG90 induced neurotoxicity. NSC363998 (free base) can be used for the research of neurodegenerative disorder such as Fragile X associated tremor/ataxia syndrome (FXTAS)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vivo]

NSC363998 (free base) (oral; 0, 5 μM) can suppress rCGG90 induced neurotoxicity[1]. Animal Model: FXTAS Drosophila model[1] Dosage: 0, 5 μM Administration: Oral (dissolved in DMSO and added to standard food) Result: Could modify ommatidial degeneration and diminished neddylation activity in the FXTAS Drosophila model.

[References]

[1]. Yunting Lin, et al. Neddylation activity modulates the neurodegeneration associated with fragile X associated tremor/ataxia syndrome (FXTAS) through regulating Sima. Neurobiol Dis. 2020 Sep;143:105013.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₂N₄O₄

[ Molecular Weight ]:
440.54

Related Compounds

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