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EG00229 free base

Names

[ CAS No. ]:
1018927-63-3

[ Name ]:
EG00229 free base

[Synonym ]:
(S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)thiophene-2-carboxamido)-5-guanidinopentanoic acid
EG00229
N2-({3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl}carbonyl)-L-arginine
L-Arginine, N2-[[3-[(2,1,3-benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-
MFCD18251520
N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine

Biological Activity

[Description]:

EG00229 is a specific inhibitor of neuropilin-1 (NRP1)/VEGF-A interaction, inhibits the binding of biotinylated VEGFA to NRP1 with IC50 of 8 uM; also demonstrates to have functional effects on cell-migration and VEGF-R2 phosphorylation.

[References]

References 1. Powell J, et al. J Med Chem. 2018 May 10;61(9):4135-4154. 2. Jarvis A, et al. J Med Chem. 2010 Mar 11;53(5):2215-26. View Related Products by Target VEGFR

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Molecular Formula ]:
C17H19N7O5S3

[ Molecular Weight ]:
497.572

[ Exact Mass ]:
497.060974

[ LogP ]:
0.63

[ Index of Refraction ]:
1.810

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds