NSC45586 free base
Names
[ CAS No. ]:
739301-85-0
[ Name ]:
NSC45586 free base
Biological Activity
[Description]:
NSC45586 free base (NCS 45586, NCI45586) is a potent, specific PHLPP2 inhibitor with IC50 of 4 uM, targets the PHLPP2 PP2C domain, suppresses MYC and triggers cell death.
[References]
1. Nowak DG, et al. J Cell Biol. 2019 May 15. pii: jcb.201902048. doi: 10.1083/jcb.201902048.
Chemical & Physical Properties
[ Molecular Formula ]:
C20H18N6O3
[ Molecular Weight ]:
390.403