159357-82-1

159357-82-1 structure

Name: NSC363998 free base
Chemical Name: NSC363998 free base
CAS Number: 159357-82-1
Molecular Formula: C₂₄H₃₂N₄O₄
Molecular Weight: 440.54
Catalog: Research Areas Neurological Disease
Create Date: 2023-04-05 11:20:07
Modify Date: 2024-07-17 12:01:22
NSC363998 (free base) is an orally active compound. NSC363998 (free base) can suppress rCGG90 induced neurotoxicity. NSC363998 (free base) can be used for the research of neurodegenerative disorder such as Fragile X associated tremor/ataxia syndrome (FXTAS)[1].

Name	NSC363998 free base

Description	NSC363998 (free base) is an orally active compound. NSC363998 (free base) can suppress rCGG90 induced neurotoxicity. NSC363998 (free base) can be used for the research of neurodegenerative disorder such as Fragile X associated tremor/ataxia syndrome (FXTAS)[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	NSC363998 (free base) (oral; 0, 5 μM) can suppress rCGG90 induced neurotoxicity[1]. Animal Model: FXTAS Drosophila model[1] Dosage: 0, 5 μM Administration: Oral (dissolved in DMSO and added to standard food) Result: Could modify ommatidial degeneration and diminished neddylation activity in the FXTAS Drosophila model.
References	[1]. Yunting Lin, et al. Neddylation activity modulates the neurodegeneration associated with fragile X associated tremor/ataxia syndrome (FXTAS) through regulating Sima. Neurobiol Dis. 2020 Sep;143:105013.

Molecular Formula	C₂₄H₃₂N₄O₄
Molecular Weight	440.54