Efavirenz
Names
[ CAS No. ]:
154598-52-4
[ Name ]:
Efavirenz
[Synonym ]:
Stocrin
EFAVIRNEZ
Efavirenz (200 mg)
(S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
(4S)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-4H-3,1-benzoxazin-2-ol
(4S)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
4H-3,1-Benzoxazin-2-ol, 6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-, (4S)-
DMP 266
SUSTIVA
MDP-266
Efavirenz
2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Ki: 2.93 nM (HIV-1 RT)[1]
[In Vitro]
[In Vivo]
[Kinase Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
422.7±55.0 °C at 760 mmHg
[ Melting Point ]:
139-141ºC
[ Molecular Formula ]:
C14H9ClF3NO2
[ Molecular Weight ]:
315.675
[ Flash Point ]:
209.4±31.5 °C
[ Exact Mass ]:
315.027405
[ PSA ]:
38.33000
[ LogP ]:
3.72
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.582
Safety Information
[ Symbol ]:
GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H410
[ Precautionary Statements ]:
P273
[ Hazard Codes ]:
N
[ Risk Phrases ]:
50
[ Safety Phrases ]:
61
[ RIDADR ]:
UN3082 - class 9 - PG 3 - DOT NA1993 - Environmentally hazardous substances, liquid, n.o.s. HI: all (not BR)
[ RTECS ]:
DM3440000
[ HS Code ]:
2942000000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2942000000
Articles
Br. J. Pharmacol. 172(7) , 1713-27, (2015)
The non-nucleoside analogue reverse transcriptase inhibitor efavirenz is associated with hepatic toxicity and metabolic disturbances. Although the mechanisms involved are not clear, recent evidence ha...
Evaluation of the in vitro/in vivo potential of five berries (bilberry, blueberry, cranberry, elderberry, and raspberry ketones) commonly used as herbal supplements to inhibit uridine diphospho-glucuronosyltransferase.Food Chem. Toxicol. 72 , 13-9, (2014)
In this study, we evaluated inhibitory potentials of popularly-consumed berries (bilberry, blueberry, cranberry, elderberry, and raspberry ketones) as herbal supplements on UGT1A1, UGT1A4, UGT1A6, UGT...
Evaluation of thein vitro/in vivodrug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibitionFood Chem. Toxicol. 68 , 117-27, (2014)
• BST204 is a purified dry extract of ginseng containing high amounts of Rh2 and Rg3. • BST204 had only weak inhibitory effects on nine CYPs and five UGTs. • It is unlikely that BST204 alter pharmacok...