α-Conotoxin TxID

Names

[ CAS No. ]:
1496617-64-1

[ Name ]:
α-Conotoxin TxID

Biological Activity

[Description]:

α-Conotoxin TxID is a potent α3β4 nAChR antagonist with an IC50 value of 12.5 nM. α-Conotoxin TxID has weak inhibition activity of closely related α6/α3β4 nAChR (IC50= 94 nM). α-Conotoxin TxID has the potential for novel smoking cessation drug development[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR
Signaling Pathways >> Neuronal Signaling >> nAChR
Research Areas >> Neurological Disease

[Target]

IC50: α3β4 nAChR


[References]

[1]. Xiaodan Li, et al. α-Conotoxin TxID and [S9K]TxID, α3β4 nAChR Antagonists, Attenuate Expression and Reinstatement of Nicotine-Induced Conditioned Place Preference in Mice. . Mar Drugs. 2020 Dec 16;18(12):646. doi: 10.3390/md18120646.  

Chemical & Physical Properties

[ Molecular Formula ]:
C58H92N18O18S5

[ Molecular Weight ]:
1489.79

Related Compounds