MF 5137

Names

[ CAS No. ]:
148927-23-5

[ Name ]:
MF 5137

[Synonym ]:
6-Amino-1-cyclopropyl-7-(3,4-dihydro-1H-isoquinolin-2-yl)-8-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
MF 5137

Biological Activity

[Description]:

MF 5137 is a potent antibacterial agent.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial
Research Areas >> Infection

[Target]

Antibacterial[1]


[In Vitro]

MF 5137 (Compound 2) is rapidly photodegraded upon UVA irradiation, yielding a toxic photoproduct. MF 5137 rapidly decreases the emission of the protein by about 80% after irradiation for 15 min. This effect is markedly reduced in anaerobic conditions[1].

[References]

[1]. Viola G, et al. 6-Aminoquinolones: photostability, cellular distribution and phototoxicity. Toxicol In Vitro. 2004 Oct;18(5):581-92.


[Related Small Molecules]

Puromycin 2HCl | Geneticin | Tunicamycin | Hygromycin B | Salinomycin | Avibactam sodium | Neomycin sulfate | Vaborbactam | Methicillin SodiuM | Rifampicin | Metronidazole | Carbenicillin disodium | Ceftazidime | Eravacycline dihydrochloride | cefotaxime sodium

Chemical & Physical Properties

[ Molecular Formula ]:
C23H23N3O3

[ Molecular Weight ]:
389.44700

[ Exact Mass ]:
389.17400

[ PSA ]:
88.56000

[ LogP ]:
4.13410

[ Storage condition ]:
2-8℃

Related Compounds