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MF-438

Names

[ CAS No. ]:
921605-87-0

[ Name ]:
MF-438

Biological Activity

[Description]:

MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an EC50 of 2.3 nM for rSCD1[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Stearoyl-CoA Desaturase (SCD)
Research Areas >> Metabolic Disease

[Target]

EC50: 2.3 nM (rSCD1)[1]


[In Vivo]

MF-438 exhibits an ED50 between 1 and 3 mg/kg in a mouse model[1].

[References]

[1]. Léger S, et al. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H18F3N5OS

[ Molecular Weight ]:
421.44

Related Compounds