Calcineurin autoinhibitory peptide

Names

[ Name ]:
Calcineurin autoinhibitory peptide

[Synonym ]:
ITSFEEAKGLDRINERMPPRRDAMP
Calcineurin autoinhibitory peptide

Biological Activity

[Description]:

Calcineurin autoinhibitory peptide is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

Research Areas >> Neurological Disease

[Target]

IC50: ~10 μM (calcineurin)[1]

[References]

[1]. Hashimoto Y, et, al. Identification of an autoinhibitory domain in calcineurin. J Biol Chem. 1990 Feb 5; 265(4): 1924-7.

[2]. Terada H, et, al. Inhibition of excitatory neuronal cell death by cell-permeable calcineurin autoinhibitory peptide. J Neurochem. 2003 Dec; 87(5): 1145-51.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂₄H₂₀₅N₃₉O₃₉S₂

[ Molecular Weight ]:
2930.32000

[ Exact Mass ]:
2928.47000

[ PSA ]:
1329.62000

[ LogP ]:
1.97210

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ WGK Germany ]:
3.0

Related Compounds

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