CALCINEURIN

[ Appearance of Characters ]:
lyophilized powder

[ Storage condition ]:
−20°C

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Evidence that calcineurin is rate-limiting for primary human lymphocyte activation.

J. Clin. Invest. 100 , 1894, (1997)

Cyclosporine (CsA) is both a clinical immunosuppressive drug and a probe to dissect intracellular signaling pathways. In vitro, CsA inhibits lymphocyte gene activation by inhibiting the phosphatase ac...

Modulator binding protein. Bovine brain protein exhibiting the Ca2+-dependent association with the protein modulator of cyclic nucleotide phosphodiesterase.

J. Biol. Chem. 252 , 4175, (1977)

Purification of cyclic 3',5'-nucleotide phosphodiesterase inhibitory protein by affinity chromatography on activator protein coupled to Sepharose.

Biochemistry 17 , 120, (1978)

The Ca2+-dependent, reversible, interaction of cyclic adenosine 3',5'-monophosphate (cAMP) phosphodiesterase with its activator has been used to purify the enzyme by affinity chromatography. Activator...

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