Calcineurin Substrate trifluoroacetate salt

Names

[ Name ]:
Calcineurin Substrate trifluoroacetate salt

[Synonym ]:
MFCD00236901
DLDVPIPGRFDRRVSVAAE

Biological Activity

[Description]:

Calcineurin substrate is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. It can be used in the calcineurin activity assay.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Neurological Disease

Peptides

[In Vitro]

Calcineurin (PP2B), a serine/threonine phosphatase controlled by cellular calcium, has been implicated in a wide variety of biological responses including lymphocyte activation, neuronal and muscle development, neurite outgrowth, and morphogenesis of vertebrate heart valves[1].

[References]

[1]. Crabtree GR, et al. Calcium, calcineurin, and the control of transcription. J Biol Chem. 2001 Jan 26;276(4):2313-6.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₉₂H₁₅₀N₂₈O₂₉

[ Molecular Weight ]:
2112.35000

[ Exact Mass ]:
2111.11000

[ PSA ]:
924.67000

[ LogP ]:
1.58550

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Endoplasmic reticulum vacuolation and unfolded protein response leading to paraptosis like cell death in cyclosporine A treated cancer cervix cells is mediated by cyclophilin B inhibition.

Biochim. Biophys. Acta 1843(11) , 2497-512, (2014)

Cyclosporine A (CsA), a widely used immunosuppressant shows cytotoxic effects by either inducing apoptosis or redirecting the cell towards non-apoptotic cell death. However, there still remains a lacu...

Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB.

Retrovirology 12 , 23, (2015)

The exact molecular mechanisms regarding HTLV-1 Tax-mediated viral gene expression and CD4 T-cell transformation have yet to be fully delineated. Herein, utilizing virus-infected primary CD4+ T cells ...

Nonradioactive assay for protein phosphatase 2B (calcineurin) activity using a partial sequence of the subunit of cAMP-dependent protein kinase as substrate.

Anal. Biochem. 216 , 147, (1994)

Currently, protein phosphatase 2B (calcineurin) activity is assayed based on release of [32P]phosphate from a 19-amino acid peptide (partial sequence of the regulatory subunit of cAMP-dependent protei...