Calcineurin autoinhibitory peptide

Modify Date: 2025-08-23 18:50:58

Calcineurin autoinhibitory peptide Structure
Calcineurin autoinhibitory peptide structure
Common Name Calcineurin autoinhibitory peptide
CAS Number 148067-21-4 Molecular Weight 2930.32000
Density N/A Boiling Point N/A
Molecular Formula C124H205N39O39S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Calcineurin autoinhibitory peptide


Calcineurin autoinhibitory peptide is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death[1][2].

 Names

Name Calcineurin autoinhibitory fragment
Synonym More Synonyms

 Calcineurin autoinhibitory peptide Biological Activity

Description Calcineurin autoinhibitory peptide is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death[1][2].
Related Catalog
Target

IC50: ~10 μM (calcineurin)[1]

References

[1]. Hashimoto Y, et, al. Identification of an autoinhibitory domain in calcineurin. J Biol Chem. 1990 Feb 5; 265(4): 1924-7.

[2]. Terada H, et, al. Inhibition of excitatory neuronal cell death by cell-permeable calcineurin autoinhibitory peptide. J Neurochem. 2003 Dec; 87(5): 1145-51.

 Chemical & Physical Properties

Molecular Formula C124H205N39O39S2
Molecular Weight 2930.32000
Exact Mass 2928.47000
PSA 1329.62000
LogP 1.97210
Storage condition -20°C

 Safety Information

Hazard Codes Xi
WGK Germany 3.0

 Synonyms

ITSFEEAKGLDRINERMPPRRDAMP
Calcineurin autoinhibitory peptide
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