Calcineurin autoinhibitory peptide

Modify Date: 2024-01-21 08:35:00

Calcineurin autoinhibitory peptide structure	Common Name	Calcineurin autoinhibitory peptide
	CAS Number	148067-21-4	Molecular Weight	2930.32000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂₄H₂₀₅N₃₉O₃₉S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Calcineurin autoinhibitory peptide

Calcineurin autoinhibitory peptide is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death[1][2].

Name	Calcineurin autoinhibitory fragment
Synonym	More Synonyms

Description	Calcineurin autoinhibitory peptide is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide could protect neurons from excitatory neuronal death[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Neurological Disease
Target	IC50: ~10 μM (calcineurin)[1]
References	[1]. Hashimoto Y, et, al. Identification of an autoinhibitory domain in calcineurin. J Biol Chem. 1990 Feb 5; 265(4): 1924-7. [2]. Terada H, et, al. Inhibition of excitatory neuronal cell death by cell-permeable calcineurin autoinhibitory peptide. J Neurochem. 2003 Dec; 87(5): 1145-51.