Nisin

Names

[ Name ]:
Nisin

[Synonym ]:
EINECS 215-807-5

Biological Activity

[Description]:

Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

Peptides

[In Vitro]

Nisin is classified as a Type A (I) lantibiotic that is synthesized from mRNA and the translated peptide contains several unusual amino acids due to post-translational modifications. Nisin is an antimicrobial peptide produced by certain Gram-positive bacteria that include Lactococcus and Streptococcus species[1].

[References]

[1]. Shin JM, et al. Biomedical applications of nisin. J Appl Microbiol. 2016 Jun;120(6):1449-65.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
2967℃

[ Molecular Formula ]:
C₁₄₃H₂₃₀N₄₂O₃₇S₇

[ Molecular Weight ]:
3354.07000

[ Flash Point ]:
>110°(230°F)

[ Exact Mass ]:
3351.55000

[ PSA ]:
1390.67000

[ LogP ]:
3.42180

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Soluble in water

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-36/37/38

[ Safety Phrases ]:
22-24/25-36-26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
QU3340000

Articles

Effect of lauric arginate, nisin Z, and a combination against several food-related bacteria.

Int. J. Food Microbiol. 188 , 135-46, (2014)

The effects of lauric arginate (LAE) and nisin Z, alone or in combination, on cell damage were investigated against Escherichia coli O157:H7, Listeria monocytogenes and Brochothrix thermosphacta, by s...

Piliation of Lactobacillus rhamnosus GG promotes adhesion, phagocytosis, and cytokine modulation in macrophages.

Appl. Environ. Microbiol. 81(6) , 2050-62, (2015)

Recently, spaCBA-encoded pili on the cell surface of Lactobacillus rhamnosus GG were identified to be key molecules for binding to human intestinal mucus and Caco-2 intestinal epithelial cells. Here, ...

Effect of combining nisin with modified atmosphere packaging on inhibition of Listeria monocytogenes in ready-to-eat turkey bologna.

Poult. Sci. 92(7) , 1930-5, (2013)

ABSTRACT The objective of this study was to evaluate the effect of nisin in combination with different types of packaging on the survival of Listeria monocytogenes in ready-to-eat low-fat turkey bolog...

Related Compounds

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