SUVN-G3031

Names

[ Name ]:
SUVN-G3031

[Synonym ]:
N-{4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl}-2-(4-morpholinyl)acetamide
4-Morpholineacetamide, N-[4-[(1-cyclobutyl-4-piperidinyl)oxy]phenyl]-
Suvn-G3031

Biological Activity

[Description]:

SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R); exhibited an IC50 of 20 nM with progressive inhibition of (R)-α-methylhistamine (0.03 µM) induced agonist activity in [35S]-GTPγS binding assay using CHO-K1 cells expressing human H3R membranes; reverses (R)-α-methylhistamine induced dipsogenia in vivo. Parkinson Disease Phase 1 Clinical

[References]

References 1. Nirogi R, et al. J Med Chem. 2019 Jan 10. doi: 10.1021/acs.jmedchem.8b01280. View Related Products by Target Histamine Receptor Parkinson Disease

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
562.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₃₁N₃O₃

[ Molecular Weight ]:
373.489

[ Flash Point ]:
294.0±30.1 °C

[ Exact Mass ]:
373.236542

[ LogP ]:
2.56

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.597

Related Compounds

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