SUVN-502 mesylate hydrate
Names
[ CAS No. ]:
1791396-45-6
[ Name ]:
SUVN-502 mesylate hydrate
[Synonym ]:
Dimesylate Dimesylate Monohydrate
1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole methanesulfonate hydrate (1:2:1)
1H-Indole, 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-, methanesulfonate, hydrate (1:2:1)
Biological Activity
[Description]:
SUVN-502 (SUVN502) is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM; shows high selectivity over 5-HT2A receptor and other 100 target sites; produces synergistic effects in extracellular levels of acetylcholine in the ventral hippocampus combined with donepezil and memantine; shows potential for treatment of Alzheimer's disease. Alzheimer Disease Phase 2 Clinical
[References]
References 1. Nirogi R, et al. J Med Chem. 2017 Mar 9;60(5):1843-1859. 2. Nirogi R, et al. J Pharm Biomed Anal. 2017 Apr 14;145:423-430. View Related Products by Target 5-HT Receptor Alzheimer Disease
Chemical & Physical Properties
[ Molecular Formula ]:
C23H34BrN3O10S3
[ Molecular Weight ]:
688.629
[ Exact Mass ]:
687.058960