1394808-82-2
1394808-82-2 structure
- Name: SUVN-G3031
- Chemical Name: Suvn-G3031
- CAS Number: 1394808-82-2
- Molecular Formula: C21H31N3O3
- Molecular Weight: 373.489
- Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
- Create Date: 2020-01-12 11:53:02
- Modify Date: 2024-01-13 18:48:50
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SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R); exhibited an IC50 of 20 nM with progressive inhibition of (R)-α-methylhistamine (0.03 µM) induced agonist activity in [35S]-GTPγS binding assay using CHO-K1 cells expressing human H3R membranes; reverses (R)-α-methylhistamine induced dipsogenia in vivo. Parkinson Disease Phase 1 Clinical
| Name | Suvn-G3031 |
|---|---|
| Synonyms |
N-{4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl}-2-(4-morpholinyl)acetamide
4-Morpholineacetamide, N-[4-[(1-cyclobutyl-4-piperidinyl)oxy]phenyl]- Suvn-G3031 |
| Description | SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R); exhibited an IC50 of 20 nM with progressive inhibition of (R)-α-methylhistamine (0.03 µM) induced agonist activity in [35S]-GTPγS binding assay using CHO-K1 cells expressing human H3R membranes; reverses (R)-α-methylhistamine induced dipsogenia in vivo. Parkinson Disease Phase 1 Clinical |
|---|---|
| References | References 1. Nirogi R, et al. J Med Chem. 2019 Jan 10. doi: 10.1021/acs.jmedchem.8b01280. View Related Products by Target Histamine Receptor Parkinson Disease |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 562.4±50.0 °C at 760 mmHg |
| Molecular Formula | C21H31N3O3 |
| Molecular Weight | 373.489 |
| Flash Point | 294.0±30.1 °C |
| Exact Mass | 373.236542 |
| LogP | 2.56 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.597 |