NSC 80793

Names

[ Name ]:
NSC 80793

[Synonym ]:
Pimprinine
5,3'-Indolyl-2-methyloxazole

Biological Activity

[Description]:

Pimprinine is a potent monoamine oxidase inhibitor, could be isolated from fermented broths. Pimprinine has antioxidative activity and anticonvulsant activity. Pimprinine inhibits tremorine-induced tremors and analgesia in mice[1][2][3].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[References]

[1]. Takeuchi T, et, al. Monoamine oxidase inhibitors isolated from fermented broths. J Antibiot (Tokyo). 1973 Mar;26(3):162-7.

[2]. Miao YP, et, al. Synthesis and antioxidative activity of 2-substituted phenyl-5-(3'-indolyl)-oxazole derivatives. Yao Xue Xue Bao. 2004 Jan;39(1):37-40.

[3]. Naik SR, et, al. Pimprinine, an extracellular alkaloid produced by Streptomyces CDRIL-312: fermentation, isolation and pharmacological activity. J Biotechnol. 2001 Jun 1;88(1):1-10.

Chemical & Physical Properties

[ Density]:
1.243g/cm3

[ Boiling Point ]:
407.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₁₀N₂O

[ Molecular Weight ]:
198.22

[ Flash Point ]:
210ºC

[ Exact Mass ]:
198.07900

[ PSA ]:
41.82000

[ LogP ]:
3.13130

[ Vapour Pressure ]:
1.74E-06mmHg at 25°C

[ Index of Refraction ]:
1.652

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%