Sovesudil

Names

[ Name ]:
Sovesudil

[Synonym ]:
Propyl 2'-(aminomethyl)-5'-[(3-fluoro-4-pyridinyl)carbamoyl]-3-biphenylcarboxylate
[1,1'-Biphenyl]-3-carboxylic acid, 2'-(aminomethyl)-5'-[[(3-fluoro-4-pyridinyl)amino]carbonyl]-, propyl ester

Biological Activity

[Description]:

Sovesudil, formally known as PHP-201, is a well-tolerated and low toxicity Rho-associated protein kinase (ROCK) inhibitor. Sovesudil can be used for the research of normal-tension glaucoma (NTG)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK

Signaling Pathways >> Stem Cell/Wnt >> ROCK

Signaling Pathways >> TGF-beta/Smad >> ROCK

[Target]

ROCK[1]

[References]

[1]. Ha A, et al. Sovesudil (locally acting rho kinase inhibitor) for the treatment of normal-tension glaucoma: the randomized phase II study [published online ahead of print, 2021 Jul 28]. Acta Ophthalmol. 2021;10.1111/aos.14949.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
545.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₂FN₃O₃

[ Molecular Weight ]:
407.438

[ Flash Point ]:
284.0±30.1 °C

[ Exact Mass ]:
407.164520

[ LogP ]:
3.73

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.619

Related Compounds

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