1333400-14-8

1333400-14-8 structure

Name: Sovesudil
Chemical Name: Propyl 2'-(aminomethyl)-5'-[(3-fluoro-4-pyridinyl)carbamoyl]-3-biphenylcarboxylate
CAS Number: 1333400-14-8
Molecular Formula: C₂₃H₂₂FN₃O₃
Molecular Weight: 407.438
Catalog: Signaling Pathways Cell Cycle/DNA Damage ROCK
Create Date: 2018-06-20 13:08:00
Modify Date: 2025-08-25 15:59:23
Sovesudil, formally known as PHP-201, is a well-tolerated and low toxicity Rho-associated protein kinase (ROCK) inhibitor. Sovesudil can be used for the research of normal-tension glaucoma (NTG)[1].

Name	Propyl 2'-(aminomethyl)-5'-[(3-fluoro-4-pyridinyl)carbamoyl]-3-biphenylcarboxylate
Synonyms	Propyl 2'-(aminomethyl)-5'-[(3-fluoro-4-pyridinyl)carbamoyl]-3-biphenylcarboxylate [1,1'-Biphenyl]-3-carboxylic acid, 2'-(aminomethyl)-5'-[[(3-fluoro-4-pyridinyl)amino]carbonyl]-, propyl ester

Description	Sovesudil, formally known as PHP-201, is a well-tolerated and low toxicity Rho-associated protein kinase (ROCK) inhibitor. Sovesudil can be used for the research of normal-tension glaucoma (NTG)[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK
Target	ROCK[1]
References	[1]. Ha A, et al. Sovesudil (locally acting rho kinase inhibitor) for the treatment of normal-tension glaucoma: the randomized phase II study [published online ahead of print, 2021 Jul 28]. Acta Ophthalmol. 2021;10.1111/aos.14949.