PF-4840154

Names

[ CAS No. ]:
1332708-14-1

[ Name ]:
PF-4840154

[Synonym ]:
PF-4840154

Biological Activity

[Description]:

PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Inflammation/Immunology

[Target]

IC50: 97 nM (rTrpA1), 23 nM (hTrpA1)[1]

[References]

[1]. Ryckmans T, et al. Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4857-4859.

[Related Small Molecules]

capsaicin | Capsazepine | EIPA | Diphenyleneiodonium chloride | HC-030031 | SKF-96365 | HC 067047 | AMG 9810 | GSK-1016790A | SAR7334 | RN-1734 | AMG-517 | SB-366791 | IcilinAG-3-5 | ML204

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C₂₆H₃₈N₆O₂

[ Molecular Weight ]:
466.619

[ Exact Mass ]:
466.305634

[ LogP ]:
6.03

[ Index of Refraction ]:
1.589

[ Storage condition ]:
2-8℃

Related Compounds

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