GSK-1016790A

Names

[ CAS No. ]:
942206-85-1

[ Name ]:
GSK-1016790A

[Synonym ]:
GSK1016790A

Biological Activity

[Description]:

GSK1016790A is a potent transient receptor potential vanilloid 4 (TRPV4) activator.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Cancer

[References]

[1]. Jin M et al. Determinants of TRPV4 activity following selective activation by small molecule agonist GSK1016790A. PLoS One, 2011 Feb 14;6(2):e16713.

[2]. MP Addison et al. NO synthase inhibition attenuates EDHF-mediated relaxation induced by TRPV4 channel agonist GSK1016790A in the rat pulmonary artery: Role of TxA2. Pharmacol Rep, 2016 Jun, 68(3):620-6.

[Related Small Molecules]

capsaicin | Capsazepine | EIPA | Diphenyleneiodonium chloride | HC-030031 | SKF-96365 | HC 067047 | AMG 9810 | SAR7334 | PF-4840154 | RN-1734 | AMG-517 | SB-366791 | IcilinAG-3-5 | ML204

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₂Cl₂N₄O₆S₂

[ Molecular Weight ]:
655.61300

[ Exact Mass ]:
654.11400

[ PSA ]:
176.23000

[ LogP ]:
5.28510

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Angiotensin II induces membrane trafficking of natively expressed transient receptor potential vanilloid type 4 channels in hypothalamic 4B cells.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(8) , R945-55, (2014)

Transient receptor potential vanilloid family type 4 (TRPV4) channels are expressed in central neuroendocrine neurons and have been shown to be polymodal in other systems. We previously reported that ...

Opposing actions of TRPV4 channel activation in the lung vasculature.

Respir. Physiol. Neurobiol. 219 , 43-50, (2015)

Transient receptor potential vanilloid 4 (TRPV4) calcium channels are known to promote endothelium-dependent relaxation of mouse mesenteric arteries but TRPV4's role in the pulmonary vasculature is un...

A mutation in TRPV4 results in altered chondrocyte calcium signaling in severe metatropic dysplasia.

Am. J. Med. Genet. A 167A , 2286-93, (2015)

Transient receptor potential cation channel, subfamily V, member 4 (TRPV4) is a polymodal modulated non-selective cation channel required for normal development and maintenance of bone and cartilage. ...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.