SAR7334

Names

[ Name ]:
SAR7334

[Synonym ]:
Acetamide, 2-chloro-N-[3-[(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]phenyl]-
2-Chloro-N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)amino]phenyl}acetamide

Biological Activity

[Description]:

SAR7334 is a potent TRPC6 (Transient receptor potential cation channel, subfamily C, member 6) inhibitor.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Others

[In Vitro]

SAR7334 is a TRPC6 inhibitor, and used for treat the fibrotic disorders, such as focal segmental glomerulosclerosis, skeletal muscle dysfunction[1].

[References]

[1]. Derivatives of aminoindanes, their preparation and their application in therapeutics. Patent WO 2011107474 A1

[Related Small Molecules]

capsaicin | Capsazepine | EIPA | Diphenyleneiodonium chloride | HC-030031 | SKF-96365 | HC 067047 | AMG 9810 | GSK-1016790A | PF-4840154 | RN-1734 | SAR 7334 | AMG-517 | SB-366791 | IcilinAG-3-5

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₂₁H₂₂ClN₃O

[ Molecular Weight ]:
367.87

[ Exact Mass ]:
349.028778

[ LogP ]:
2.13

[ Index of Refraction ]:
1.697

Related Compounds

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