Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CS-2357
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: PF-4840154
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DC Chemicals Limited
China
Product Name: PF-4840154
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-Pyrimidinecarboxamide, 4-[(2-Methylpropyl)amino]-N-(phenylmethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-
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1332708-14-1

1332708-14-1 structure

1332708-14-1 structure

Name: PF-4840154
Chemical Name: PF-4840154
CAS Number: 1332708-14-1
Molecular Formula: C₂₆H₃₈N₆O₂
Molecular Weight: 466.619
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2018-01-28 12:37:03
Modify Date: 2025-08-23 14:29:00
PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively.

Name	PF-4840154
Synonyms	PF-4840154

Description	PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Inflammation/Immunology
Target	IC50: 97 nM (rTrpA1), 23 nM (hTrpA1)[1]
References	[1]. Ryckmans T, et al. Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4857-4859.

Density	1.2±0.1 g/cm3
Molecular Formula	C₂₆H₃₈N₆O₂
Molecular Weight	466.619
Exact Mass	466.305634
LogP	6.03
Index of Refraction	1.589
Storage condition	2-8℃

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