Merbromin
Names
[ CAS No. ]:
129-16-8
[ Name ]:
Merbromin
[Synonym ]:
Broept
flavurol
Marbromin
Emcerol
Mercury dibromofluorescein disodium salt
gynochrome
MFCD00013081
mercurome
Chromine
domf
Ekakrome
EINECS 204-933-6
Biological Activity
[Description]:
[Related Catalog]:
[Related Small Molecules]
Chemical & Physical Properties
[ Melting Point ]:
≥300 °C
[ Molecular Formula ]:
C20H10Br2HgNa2O6
[ Molecular Weight ]:
752.67
[ PSA ]:
113.63000
[ LogP ]:
3.59240
[ Stability ]:
Stable. Incompatible with strong oxidizing agents, strong acids.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LM5250000
- CHEMICAL NAME :
- Fluorescein, 2',7'-dibromo-4'-(hydroxymercurio)-, disodium salt
- CAS REGISTRY NUMBER :
- 129-16-8
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C20-H8-Br2-Hg-O6.2Na
- MOLECULAR WEIGHT :
- 750.67
- WISWESSER LINE NOTATION :
- T C666 BO EVJ D-HG-Q FE IR BVQ& LE MQ &-NA- 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory stimulation
MUTATION DATA
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TEST SYSTEM :
- Yeast - Saccharomyces cerevisiae
- REFERENCE :
- EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 31,97,1979 *** REVIEWS *** TOXICOLOGY REVIEW SDGTB3 Seminars in Drug Treatment. (New York, NY) V.1-3, 1971-74. Discontinued. Volume(issue)/page/year: 1,177,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO MERCURY, ARYL AND INORGANIC-air:CL 0.1 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 44650 No. of Facilities: 586 (estimated) No. of Industries: 5 No. of Occupations: 10 No. of Employees: 7896 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 44650 No. of Facilities: 372 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 5294 (estimated) No. of Female Employees: 3955 (estimated)
Safety Information
[ Symbol ]:
GHS06, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300 + H310 + H330-H373-H410
[ Precautionary Statements ]:
P260-P273-P280-P301 + P310 + P330-P302 + P352 + P310-P304 + P340 + P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T+:Verytoxic;N:Dangerous for the environment;
[ Risk Phrases ]:
R26/27/28;R33;R50/53
[ Safety Phrases ]:
S13-S28-S36-S45-S60-S61
[ RIDADR ]:
UN 2025 6.1/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
LM5250000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
Articles
Angle Orthod. 81(5) , 884-8, (2011)
To compare the effectiveness of three different motivational techniques for maintaining good oral hygiene during fixed appliance orthodontic treatment.A total of 62 adolescents in the age range of 12-...
Chronic bilateral otomycosis caused by Aspergillus niger.Mycoses 47(1-2) , 82-4, (2004)
Aspergillus niger, an opportunistic filamentous fungus, was identified as the cause of chronic bilateral otomycosis in a 46-year-old female patient who was unresponsive to different drugs. The patient...
Merbromine-induced pustular contact dermatitis.Contact Dermatitis 40(4) , 219, (1999)