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Sulfacetamide sodium

Names

[ CAS No. ]:
127-56-0

[ Name ]:
Sulfacetamide sodium

[Synonym ]:
Sulfacetamide sodium salt
Sodium acetyl[(4-aminophenyl)sulfonyl]azanide
UNII-30760ZE777
Sulfacetamide sodium anhydrous
Sulfacetamide sodium
acetamide, N-[(4-aminophenyl)sulfonyl]-, monosodium salt
SODIUM SULFACETAMIDE
Sulf 10
MFCD00149555
Acetamide, N-[(4-aminophenyl)sulfonyl]-, sodium salt (1:1)
N-Acetylsulfanilamide Sodium Salt Hydrate
Sodium N-sulfanilylacetamide
SULPHACETAMIDE SODIUM
N-Acetyl-4-aminobenzenesulfonamide Sodium Salt Hydrate
sodium,acetyl-(4-aminophenyl)sulfonylazanide
EINECS 204-848-4
SulfacetaMide SodiuM Salt Hydrate
Sulfacetamide (Sodium)

Biological Activity

[Description]:

Sulfacetamide Sodium is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.Target: AntibacterialSulfacetamide is a sulfonamide antibiotic. Sulfacetamide is able to inhibit the growth of all isolated strains. Depending on the type of bacteria concentrations of 0.006 up to 6.4% sodium sulfacetamide proved to be effective. Simultaneously, all patients were treated with sulfacetamide containing ointment and/or eye drops 4 times daily for maximum of 14 days. With swabs taken at intervals of 7 and 14 days no bacterial growth was detected. Sulfacetamide 10% topical lotion, sold under the brand name Klaron or Ovace, is approved for the treatment of acne and seborrheic dermatitis. Sulfacetamide has been investigated for use in the treatment of pityriasis versicolor and rosacea. It may also have anti-inflammatory properties when used to treat blepharitis or conjunctivitis. It is believed to work by limiting the presence of folic acid which bacteria need to survive. It has been suggested that sulfacetamide may also serve as a treatment for mild forms of hidradenitis suppurativa. Sulfacetamide has antibacterial activity and is used to control acne. Some research indicates that sulfacetamide derivatives may act as antifungals by an CYP51A1-independent mechanism [1-4].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial
Research Areas >> Infection

[References]

[1]. Del Rosso, J.Q., Evaluating the role of topical therapies in the management of rosacea: focus on combination sodium sulfacetamide and sulfur formulations. Cutis, 2004. 73(1 Suppl): p. 29-33.

[2]. Mastrolorenzo, A. and C.T. Supuran, Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives. Met Based Drugs, 2000. 7(1): p. 49-54.

[3]. http://www.drugs.com/mtm/klaron.html

[4]. Roth, H.W., et al., [The effective antibacterial spectrum of sulfacetamide]. Klin Monbl Augenheilkd, 1992. 200(3): p. 182-6.


[Related Small Molecules]

Puromycin 2HCl | Geneticin | Tunicamycin | Hygromycin B | Salinomycin | Avibactam sodium | Neomycin sulfate | Vaborbactam | Methicillin SodiuM | Rifampicin | Metronidazole | Carbenicillin disodium | Ceftazidime | Eravacycline dihydrochloride | cefotaxime sodium

Chemical & Physical Properties

[ Boiling Point ]:
450.8ºC at 760 mmHg

[ Molecular Formula ]:
C8H9N2NaO3S

[ Molecular Weight ]:
236.223

[ Flash Point ]:
226.4ºC

[ Exact Mass ]:
236.023163

[ PSA ]:
88.85000

[ LogP ]:
1.93230

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC8480000
CHEMICAL NAME :
Acetamide, N-sulfanilyl-, monosodium salt
CAS REGISTRY NUMBER :
127-56-0
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C8-H9-N2-O3-S.Na
MOLECULAR WEIGHT :
236.24
WISWESSER LINE NOTATION :
ZR DSWMV1 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Yeast - Saccharomyces cerevisiae
DOSE/DURATION :
5 ppm
REFERENCE :
RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione Umana. Review of Science and Technology of Food and Human Nutrition. (Bologna, Italy) V.5-6, 1975-76. Discontinued. Volume(issue)/page/year: 6,161,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83071 No. of Facilities: 176 (estimated) No. of Industries: 5 No. of Occupations: 4 No. of Employees: 500 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83071 No. of Facilities: 185 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 6788 (estimated) No. of Female Employees: 3730 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
UN 3249

[ WGK Germany ]:
3

[ RTECS ]:
AC8480000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2924299090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds