OSBPL7-IN-1
Names
[ CAS No. ]:
1269826-44-9
[ Name ]:
OSBPL7-IN-1
Biological Activity
[Description]:
OSBPL7-IN-1 is an orally active oxysterol binding protein like 7 (OSBPL7) inhibitor. OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].
[Related Catalog]:
[Target]
OSBPL7[1] ABCA1[1]
[In Vitro]
OSBPL7-IN-1 (compound G or Cpd G; 1-10 µM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux[1].
[In Vivo]
OSBPL7-IN-1 (100 mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria and prevents renal function decline in mouse models of proteinuric kidney disease[1]. Animal Model: Female Balb/c mice induced by Adriamycin (ADR)[1] Dosage: 100 mg/kg Administration: Oral gavage; daily; for 28 days Result: Normalized proteinuria, and significantly reduced renal fibrosis and renal functional decline.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C20H19Cl2F3N2O3
[ Molecular Weight ]:
463.28