Atorvastatin lactone

Names

[ Name ]:
Atorvastatin lactone

[Synonym ]:
5-(4-Fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N,4-di(phenyl)-2-propan-2-ylpyrrole-3-carboxamide
Benzeneacetamide,a-cyano-4-methoxy
5-(4-Fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide
5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
Atorvastatin lactone
1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-
4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
Atorvastatin Impurity 23

Biological Activity

[Description]:

Atorvastatin lactone is a prodrug form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[References]

[1]. Valesky RJ, et al. Automated enzyme inhibition assay method for the determination of atorvastatin-derived HMG-CoA reductase inhibitors in human plasma using radioactivity detection. J Pharmacol Toxicol Methods. 2008 Jan-Feb;57(1):61-9.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
674.8±55.0 °C at 760 mmHg

[ Melting Point ]:
103-106ºC

[ Molecular Formula ]:
C₃₃H₃₃FN₂O₄

[ Molecular Weight ]:
540.625

[ Flash Point ]:
361.9±31.5 °C

[ Exact Mass ]:
540.242432

[ PSA ]:
80.56000

[ LogP ]:
4.30

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.617

Safety Information

[ RIDADR ]:
UN 2811 6.1 / PGII

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%