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2-Hydroxy atorvastatin lactone

Names

[ CAS No. ]:
163217-74-1

[ Name ]:
2-Hydroxy atorvastatin lactone

[Synonym ]:
5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N-(2-hydroxyphenyl)-4-phenyl-2-propan-2-ylpyrrole-3-carboxamide

Biological Activity

[Description]:

2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1][2].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Guo CX, et al. Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices. Xenobiotica. 2012;42(8):784‐790.

[2]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.

Chemical & Physical Properties

[ Melting Point ]:
110-112ºC

[ Molecular Formula ]:
C33H33FN2O5

[ Molecular Weight ]:
556.62400

[ Exact Mass ]:
556.23700

[ PSA ]:
100.79000

[ LogP ]:
6.57210

Related Compounds