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4-hydroxy Atorvastatin lactone

Names

[ CAS No. ]:
163217-70-7

[ Name ]:
4-hydroxy Atorvastatin lactone

[Synonym ]:
5-(4-Fluorophenyl)-N-(4-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
4-Hydroxy Atorvastatin Lactone
UNII-1316I46GEX

Biological Activity

[Description]:

4-Hydroxy Atorvastatin lactone is a metabolite of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[References]

[1]. Jemal M, et al. Quantitation of the acid and lactone forms of atorvastatin and its biotransformation products in human serum by high-performance liquid chromatography with electrospray tandem mass spectrometry. Rapid Commun Mass Spectrom. 1999;13(11):1003-15.

Chemical & Physical Properties

[ Melting Point ]:
103-106℃

[ Molecular Formula ]:
C33H33FN2O5

[ Molecular Weight ]:
556.62

[ Exact Mass ]:
556.23700

[ PSA ]:
100.79000

[ LogP ]:
6.57210

Related Compounds