<Suppliers Price>

Atorvastatin lactone D5

Names

[ CAS No. ]:
1217749-86-4

[ Name ]:
Atorvastatin lactone D5

[Synonym ]:
5-(4-Fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-N-phenyl-4-(2H5)phenyl-1H-pyrrole-3-carboxamide
1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N-phenyl-4-(phenyl-d5)-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-

Biological Activity

[Description]:

Atorvastatin lactone D5 is a deuterated form of Atorvastatin lactone (HY-101873). Atorvastatin lactone is a prodrug form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[References]

[1]. Valesky RJ, et al. Automated enzyme inhibition assay method for the determination of atorvastatin-derived HMG-CoA reductase inhibitors in human plasma using radioactivity detection. J Pharmacol Toxicol Methods. 2008 Jan-Feb;57(1):61-9.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
674.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C33H28D5FN2O4

[ Molecular Weight ]:
545.655

[ Flash Point ]:
361.9±31.5 °C

[ Exact Mass ]:
545.273804

[ LogP ]:
4.30

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.617

Related Compounds