Ro 41-0960

Names

[ Name ]:
Ro 41-0960

[Synonym ]:
OR 1139
3,4-dihydroxy-5-nitrophenyl 2-fluorophenyl ketone
(3,4-Dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone
2'-fluoro-3,4-dihydroxy-5-nitrobenzophenone
3,4-dihydroxy-5-nitro-2'-fluorobenzophenone
Ro 41-0960
2'-Fluoro-3,4-dihydroxy-5-nitrobenzophenone
Methanone,(3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)

Biological Activity

[Description]:

Ro 41-0960 is a selective catechol-O-methyltransferase(COMT) inhibitor[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> COMT

Research Areas >> Neurological Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> COMT

[References]

[1]. Storch A, et al. Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons. Mol Pharmacol. 2000 Mar;57(3):589-94.

Chemical & Physical Properties

[ Density]:
1.536g/cm3

[ Boiling Point ]:
489.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₃H₈FNO₅

[ Molecular Weight ]:
277.20500

[ Flash Point ]:
250.1ºC

[ Exact Mass ]:
277.03900

[ PSA ]:
103.35000

[ LogP ]:
2.89930

[ Vapour Pressure ]:
3.2E-10mmHg at 25°C

[ Index of Refraction ]:
1.656

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PC4952300

CHEMICAL NAME :: Methanone, (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)-

CAS REGISTRY NUMBER :: 125628-97-9

LAST UPDATED :: 199509

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H8-F-N-O5

MOLECULAR WEIGHT :: 277.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 312 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 72,952,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 136 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 69,64,1991

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
PC4952300

Articles

Organic cation transporter 3 contributes to norepinephrine uptake into perivascular adipose tissue.

Am. J. Physiol. Heart Circ. Physiol. 309 , H1904-14, (2015)

Perivascular adipose tissue (PVAT) reduces vasoconstriction to norepinephrine (NE). A mechanism by which PVAT could function to reduce vascular contraction is by decreasing the amount of NE to which t...

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters.

J. Biol. Chem. 290 , 13992-4003, (2015)

Neurotransmitter:sodium symporters (NSSs) terminate neurotransmission by Na(+)-dependent reuptake of released neurotransmitters. Previous studies suggested that Na(+)-binding reconfigures dynamically ...

Elevated expression of catechol-O-methyltransferase is associated with labor and increased prostaglandin E2production by human fetal membranes

Am. J. Obstet. Gynecol. 201(5) , 496.e1-7, (2009)

Objective The purpose of this study was to evaluate the expression and function of catechol-O-methyltransferase in human fetal membranes at term.

Related Compounds

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