κ-Bungarotoxin

Names

[ CAS No. ]:
124511-67-7

[ Name ]:
κ-Bungarotoxin

Biological Activity

[Description]:

κ-Bungarotoxin (κ-Bgt) is a potent, selective, and slowly reversible antagonist of α3β2 neuronal nicotinic acetylcholine receptors with an IC50 of 2.30 nM[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR
Signaling Pathways >> Neuronal Signaling >> nAChR
Research Areas >> Neurological Disease

[Target]

IC50: 2.30 nM (recombinantly expressed in P. pastoris against α3β2)[1]


[References]

[1]. Grant GA, et al. Differential roles for disulfide bonds in the structural integrity and biological activity of kappa-Bungarotoxin, a neuronal nicotinic acetylcholine receptor antagonist. Biochemistry. 1998 Sep 1;37(35):12166-71.  

Chemical & Physical Properties

[ Molecular Formula ]:
C303H475N91O97S10

[ Molecular Weight ]:
7265.22

Related Compounds