ML133 HCl

Names

[ Name ]:
ML133 HCl

[Synonym ]:
N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride
ML133 hydrochloride
ML133 HCL
1-Naphthalenemethanamine (N-[(4-methoxyphenyl)methyl]

Biological Activity

[Description]:

ML133 (hydrochloride) is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: 1.8 μM (Kir2 at pH 7.4), 290 nM (Kir2 at pH 8.5)[1].

[References]

[1]. Wang HR, et al. Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem Biol. 2011 Aug 19;6(8):845-56.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₀ClNO

[ Molecular Weight ]:
313.82100

[ Exact Mass ]:
313.12300

[ PSA ]:
21.26000

[ LogP ]:
5.33110

[ Appearance of Characters ]:
white to tan

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: ≥10mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H318-H335-H400

[ Precautionary Statements ]:
P261-P273-P280-P305 + P351 + P338

[ Hazard Codes ]:
Xn,N

[ Risk Phrases ]:
22-37/38-41-50/53

[ Safety Phrases ]:
26-39-60-61

[ RIDADR ]:
UN 3077 9 / PGIII

[ HS Code ]:
2922299090

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

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