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(D-Pro2,D-Trp6.8,Nle10)-Neurokinin B

Names

[ CAS No. ]:
109212-72-8

[ Name ]:
(D-Pro2,D-Trp6.8,Nle10)-Neurokinin B

[Synonym ]:
ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2
(D-PRO2,D-TRP6,8,NLE10)-NEUROKININ B
(D-Pro2,D-Trp6
DPHDFWVWL-NLE-NH2
H-ASP-D-PRO-HIS-ASP-PHE-D-TRP-VAL-D-TRP-LEU-NLE-NH2

Biological Activity

[Description]:

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin B shows no influence on Substance P or Neurokinin A[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[In Vivo]

在大鼠中，(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B (1 mg/kg i.v.) 显着减少 Substance P- 和 Neurokinin B-， 但不减少乙酰胆碱或 Neurokinin A 诱导的流涎。(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B 可将麻醉大鼠的血压降低 35% 至 40%[2]。

[References]

[1]. H I Jacoby, et al. Differentiation of multiple neurokinin receptors in the guinea pig ileum. Life Sci. 1986 Nov 24;39(21):1995-2003.  

[2]. C W Murray, et al. Neurokinin-induced salivation in the anesthetized rat: a three receptor hypothesis. J Pharmacol Exp Ther. 1987 Aug;242(2):500-6.  

Chemical & Physical Properties

[ Molecular Formula ]:
C67H87N15O14

[ Molecular Weight ]:
1326.50000

[ Exact Mass ]:
1325.66000

[ PSA ]:
457.08000

[ LogP ]:
5.63230

Related Compounds