[D-Pro2,D-Phe7,D-Trp9]-Substance P

Names

[ Name ]:
[D-Pro2,D-Phe7,D-Trp9]-Substance P

[Synonym ]:
substance P,Pro(2)-Phe(7)-Trp(9)
Substance P,(D-Pro2,D-Phe7,D-Trp9)
ARG-D-PRO-LYS-PRO-GLN-GLN-D-PHE-PHE-D-TRP-LEU-MET-NH2
(D-PROLINE2,D-PHENYLALANINE7,D-TRYPTOPHAN9)SUBSTANCE P)
(D-PRO2,D-PHE7,D-TRP9)-SUBSTANCE P
H-ARG-D-PRO-LYS-PRO-GLN-GLN-D-PHE-PHE-D-TRP-LEU-MET-NH2

Biological Activity

[Description]:

[D-Pro2,D-Phe7,D-Trp9] Substance P is a Substance P (HY-P0201) analogue. [D-Pro2,D-Phe7,D-Trp9] Substance P is an inhibitor of Substance P. [D-Pro2,D-Phe7,D-Trp9] Substance P contracts guinea-pig ileum (GPI) indirectly[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

Substance P[2]

[In Vitro]

[D-Pro2,D-Phe7,D-Trp9] Substance P (10-100 μM; 2 min or 10 min) produces dose-related contractions of the guinea-pig ileum and in the rabbit external jugular vein[1].

[In Vivo]

[D-Pro2,D-Phe7,D-Trp9] Substance P (1-2 mg/kg; i.v.; once) inhibits the salivary secretion which was induced by Substance P in rats. In the dosage range at 1-1.5 mg/kg slightly increases the blood pressure[2].

[References]

[1]. Hawcock AB, et al. Agonist effects of [D-Pro2,D-Phe7,D-Trp9]substance P--evidence for different receptors. Eur J Pharmacol. 1982 May 7;80(1):135-8.

[2]. Folkers K, et al. Chemical design of antagonists of substance P. Acta Physiol Scand. 1981 Apr;111(4):505-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇₂H₁₀₅N₁₉O₁₃S

[ Molecular Weight ]:
1476.79000

[ Exact Mass ]:
1475.79000

[ PSA ]:
557.72000

[ LogP ]:
6.28670

Related Compounds

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