PCI-33380

Names

[ CAS No. ]:
1022899-36-0

[ Name ]:
PCI-33380

Biological Activity

[Description]:

PCI-33380 is an irreversible Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe).

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

Research Areas >> Others

[Target]

BTK[1][2].

[References]

[1]. Zuo Y, et al. A novel 2,5-diaminopyrimidine-based affinity probe for Bruton's tyrosine kinase. Sci Rep. 2015 Nov 4;5:16136.

[2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.

[Related Small Molecules]

Acalabrutinib | GDC-0853 | Evobrutinib | AVL-292 | (±)-Zanubrutinib | ONO-4059 | BMX-IN-1 | GDC-0834 | SNS-062 | RN486 | LFM-A13 | Vecabrutinib | CGI-1746 | BMS-986195 | CNX-774

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₆H₅₂BF₂N₁₁O₃

[ Molecular Weight ]:
855.78

[ Storage condition ]:
2-8℃

Related Compounds

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