<Suppliers Price>

ONO-4059

Names

[ CAS No. ]:
1351636-18-4

[ Name ]:
ONO-4059

[Synonym ]:
tirabrutinib
MFCD28386296
8H-Purin-8-one, 6-amino-7,9-dihydro-9-[(3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-
UNII:LXG44NDL2T
6-Amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one
ONO-BKT
ONO-4059

Biological Activity

[Description]:

Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
Research Areas >> Cancer

[Target]

IC50: 2.2 nM (BTK)[1]


[References]

[1]. Burger JA. Bruton's tyrosine kinase (BTK) inhibitors in clinical trials. Curr Hematol Malig Rep, 2014 Mar, 9(1):44-9.

[2]. Harriet S. Walter et al. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies. Blood, 2016 Jan 28, 127(4): 411-419.


[Related Small Molecules]

Acalabrutinib | GDC-0853 | Evobrutinib | AVL-292 | (±)-Zanubrutinib | BMX-IN-1 | GDC-0834 | SNS-062 | RN486 | LFM-A13 | Vecabrutinib | CGI-1746 | ONO4059 hydrochloride | BMS-986195 | CNX-774

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
672.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H22N6O3

[ Molecular Weight ]:
454.481

[ Flash Point ]:
360.2±34.3 °C

[ Exact Mass ]:
454.175354

[ LogP ]:
2.31

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.700

Related Compounds