1351636-18-4

1351636-18-4 structure

Name: ONO-4059
Chemical Name: tirabrutinib
CAS Number: 1351636-18-4
Molecular Formula: C₂₅H₂₂N₆O₃
Molecular Weight: 454.481
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Btk
Create Date: 2018-09-28 14:16:22
Modify Date: 2025-08-24 18:10:12
Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM.

Name	tirabrutinib
Synonyms	tirabrutinib MFCD28386296 8H-Purin-8-one, 6-amino-7,9-dihydro-9-[(3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)- UNII:LXG44NDL2T 6-Amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one ONO-BKT ONO-4059

Description	Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk Research Areas >> Cancer
Target	IC50: 2.2 nM (BTK)[1]
References	[1]. Burger JA. Bruton's tyrosine kinase (BTK) inhibitors in clinical trials. Curr Hematol Malig Rep, 2014 Mar, 9(1):44-9. [2]. Harriet S. Walter et al. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies. Blood, 2016 Jan 28, 127(4): 411-419.