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GDC-0853

Names

[ CAS No. ]:
1434048-34-6

[ Name ]:
GDC-0853

[Synonym ]:
2-[3'-(Hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(3-oxetanyl)-1-piperazinyl]-2-pyridinyl}amino)-6-oxo-1,6-dihydro-3,4'-bipyridin-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one
2H-Cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, 2-[1,6-dihydro-3'-(hydroxymethyl)-1-methyl-5-[[5-[(2S)-2-methyl-4-(3-oxetanyl)-1-piperazinyl]-2-pyridinyl]amino]-6-oxo[3,4'-bipyridin]-2'-yl]-3,4,7,8-tetrahydro-7,7-dimethyl-
GDC-0853

Biological Activity

[Description]:

GDC-0853 is a potent, selective, and noncovalent bruton's tyrosine kinase (Btk) inhibitor with a Ki of 0.91 nM.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
Research Areas >> Cancer

[Related Small Molecules]

Acalabrutinib | Evobrutinib | AVL-292 | (±)-Zanubrutinib | ONO-4059 | BMX-IN-1 | GDC-0834 | SNS-062 | RN486 | LFM-A13 | Vecabrutinib | CGI-1746 | BMS-986195 | CNX-774 | PRN 1008

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
936.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C37H44N8O4

[ Molecular Weight ]:
664.797

[ Flash Point ]:
520.0±34.3 °C

[ Exact Mass ]:
664.348572

[ LogP ]:
1.59

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.725

Related Compounds