1022899-36-0

1022899-36-0 structure

Name: PCI-33380
Chemical Name: PCI-33380
CAS Number: 1022899-36-0
Molecular Formula: C₄₆H₅₂BF₂N₁₁O₃
Molecular Weight: 855.78
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Btk
Create Date: 2019-01-20 11:02:25
Modify Date: 2025-08-26 14:16:39
PCI-33380 is an irreversible Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe).

Name	PCI-33380

Description	PCI-33380 is an irreversible Bruton's Tyrosine Kinase (BTK) inhibitor (fluorescent probe).
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk Research Areas >> Others
Target	BTK[1][2].
References	[1]. Zuo Y, et al. A novel 2,5-diaminopyrimidine-based affinity probe for Bruton's tyrosine kinase. Sci Rep. 2015 Nov 4;5:16136. [2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.