PGLa

Names

[ CAS No. ]:
102068-15-5

[ Name ]:
PGLa

[Synonym ]:
PGLa

Biological Activity

[Description]:

PGLa is an antimicrobial peptide. PGLa is known to be bacteriostatic against both Gram-positive and Gram-negative bacteria.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

Peptides

[Target]

Anti-bacteria[1]

[In Vitro]

PGLa is known to be bacteriostatic against both Gram-positive and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Streptococcus pyogenes, and Staphylococcus aureus), without much selectivity between the two types of bacterial cells. PGLa is synthesized as a native (the wild type) peptide and as a mutant with a norleucine instead of methionine at position 2Met (designated PGLa(Nle)).

[References]

[1]. Radchenko DS, et al. Does a methionine-to-norleucine substitution in PGLa influence peptide-membrane interactions? Biochim Biophys Acta. 2016 Sep;1858(9):2019-27.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₈₈H₁₆₂N₂₆O₂₂S

[ Molecular Weight ]:
1968.45000

[ Exact Mass ]:
1967.21000

[ PSA ]:
800.72000

[ LogP ]:
4.65010

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Synergistic transmembrane insertion of the heterodimeric PGLa/magainin 2 complex studied by solid-state NMR.

Biochim. Biophys. Acta 1788 , 1667-1679, (2009)

The skin secretions of amphibians are a rich source of antimicrobial peptides. The two antimicrobial peptides PGLa and magainin 2, isolated from the African frog Xenopus laevis, have been shown to act...

Synergistic insertion of antimicrobial magainin-family peptides in membranes depends on the lipid spontaneous curvature.

Biophys. J. 104(6) , L9-11, (2013)

PGLa and magainin 2 (MAG2) are amphiphilic antimicrobial peptides from frog skin with known synergistic activity. The orientation of the two helices in membranes was studied using solid-state (15)N-NM...

Rapid-prototyped and salt-leached PLGA scaffolds condition cell morpho-functional behavior.

J. Biomed. Mater. Res. A 85(2) , 466-76, (2008)

Three dimensional scaffolds microfabricated using pressure-assisted microsyringe (PAM) with controlled geometry and porous membranes obtained using salt leaching were both tested with three different ...

Related Compounds

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