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A7132

Names

[ CAS No. ]:
100490-21-9

[ Name ]:
A7132

[Synonym ]:
1-p-fluorophenyl-6-fluoro-1,4-dihydro-4-oxo-7(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid
6-fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
sarafloxacin
A7132

Biological Activity

[Description]:

A7132 is an antibacterial agent. A7132 possess broad and potent antibacterial activity.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial
Research Areas >> Infection

[Target]

Antibacterial[1]


[In Vitro]

A7132 (Compound 31) shows great oral activity against S. aureus NCTC 10649, E. coli Juhl and P. aeruginosa 5007 with MICs of 0.25, 0.05 and 0.39 μg/mL, respectively[1].

[References]

[1]. Chu DT, et al. Synthesis and structure-activity relationships of new arylfluoronaphthyridine antibacterialagents. J Med Chem. 1986 Nov;29(11):2363-9.


[Related Small Molecules]

Puromycin 2HCl | Geneticin | Tunicamycin | Hygromycin B | Salinomycin | Avibactam sodium | Neomycin sulfate | Vaborbactam | Methicillin SodiuM | Rifampicin | Metronidazole | Carbenicillin disodium | Ceftazidime | Eravacycline dihydrochloride | cefotaxime sodium

Chemical & Physical Properties

[ Molecular Formula ]:
C19H16F2N4O3

[ Molecular Weight ]:
386.35200

[ Exact Mass ]:
386.11900

[ PSA ]:
87.46000

[ LogP ]:
2.16550

Related Compounds

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