Regio-and stereoselective synthesis of spirooxindole 1′-nitro pyrrolizidines with five concurrent stereocenters under aqueous medium and their bioprospection using …
CEP Galvis, VV Kouznetsov
Index: Puerto Galvis, Carlos E.; Kouznetsov, Vladimir V. Organic and Biomolecular Chemistry, 2013 , vol. 11, # 42 p. 7372 - 7386
Full Text: HTML
Citation Number: 22
Abstract
A highly regio-and stereoselective method has been developed and expanded for the synthesis of a 20-membered library of spirooxindole 1′-nitro pyrrolizidines via 1, 3-dipolar cycloaddition of azomethine ylides, generated in situ by a decarboxylative route from a common set of diverse isatins and L-proline derivatives, with substituted β-nitrostyrenes under aqueous medium. Among various reaction conditions, water proved to be ...
Related Articles:
Synthesis of novel 5-substituted indirubins as protein kinases inhibitors
[Beauchard, Anne; Ferandin, Yoan; Frere, Stephane; Lozach, Olivier; Blairvacq, Melina; Meijer, Laurent; Thiery, Valerie; Besson, Thierry Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 18 p. 6434 - 6443]
[Kumar, Chebolu Naga Sesha Sai Pavan; Devi, Chebrolu Lavanya; Rao, Vaidya Jayathirtha; Palaniappan, Srinivasan Synlett, 2008 , # 13 p. 2023 - 2027]
[Li, Jian; Liu, Yuejin; Li, Chunju; Jia, Xueshun Chemistry - A European Journal, 2011 , vol. 17, # 27 p. 7409 - 7413]
[Cheng, Ying; Goon, Simon; Meth-Cohn, Otto Chemical Communications, 1996 , # 11 p. 1395 - 1396]
[Cheng, Ying; Goon, Simon; Meth-Cohn, Otto Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 10 p. 1619 - 1625]