Chemistry–A European Journal

Syntheses of Spirocyclic Oxindole??Butenolides by Using Three??Component Cycloadditions of Isocyanides, Allenoates, and Isatins

J Li, Y Liu, C Li, X Jia

Index: Li, Jian; Liu, Yuejin; Li, Chunju; Jia, Xueshun Chemistry - A European Journal, 2011 , vol. 17, # 27 p. 7409 - 7413

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Abstract

Spirocyclic oxindoles have been coined priviledged targets due to their common occurence in natural products and clinical pharmaceuticals.[1, 2] The key structural characteristic of these compounds is the spiro-ring fusion at the 3-position of the oxindole, which gives increasing molecular complexity and significant biological activities, including insecticidal, antitumor, anthelmintic, and antibacterial properties.[3] For example, the most notable ...

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