Deep eutectic solvent promoted highly efficient synthesis of N, N'-diarylamidines and formamides

N Azizi, E Gholibeglo, M Babapour, H Ghafuri…

Index: Azizi, Najmadin; Gholibeglo, Elham; Babapour, Mahbobe; Ghafuri, Hossein; Bolourtchian, Seyed Mohammad Comptes Rendus Chimie, 2012 , vol. 15, # 9 p. 768 - 773

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Citation Number: 14

Abstract

A deep eutectic solvent was used as a dual catalyst and reaction medium for the efficient N- formylation of aromatic amines without hazardous organic solvent and catalyst. Treatment of aromatic amines with trimethyl orthoformate and formic acid in deep eutectic solvent at 70° C gives the corresponding N-formyl derivatives in good to excellent yields. This simple ammonium deep eutectic solvent, easily synthesized from choline chloride and SnCl2, ...