SKI-I structure
|
Common Name | SKI-I | ||
---|---|---|---|---|
CAS Number | 306301-68-8 | Molecular Weight | 406.43600 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C25H18N4O2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of SKI-ISKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines[1][2]. |
Name | ski-i |
---|---|
Synonym | More Synonyms |
Description | SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines[1][2]. |
---|---|
Related Catalog | |
Target |
IC50: 1.2 μM (ST-hSK); 11 μM (hERK2)[1] |
In Vitro | SKI-I (Compound I; 5 μg/mL) inhibits SK activity by 99%[1]. SKI-I (10 μM; 24 h) induces the apoptosis of T24 cells[1]. |
References |
Molecular Formula | C25H18N4O2 |
---|---|
Molecular Weight | 406.43600 |
Exact Mass | 406.14300 |
PSA | 90.37000 |
LogP | 5.24350 |
Hazard Codes | Xi |
---|
Sphingosine Kinase Inhibitor, SKI-I |
5-naphthalen-2-yl-1H-pyrazol-3-carboxylic acid (2-hydroxynaphthalen-1-ylmethylene)-hydrazide |