SKI-2852
Modify Date: 2023-01-18 09:56:01
SKI-2852 structure
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Common Name | SKI-2852 | ||
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| CAS Number | 1346554-47-9 | Molecular Weight | 543.658 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H34FN5O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SKI-2852A highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively; demonstrates no CYP and PXR liabilities, excellent PK profiles across species, and highly potent and sustainable PD activity; significantly reduces blood glucose and HbA1c levels and improves the lipid profiles in ob/ob mice, synergistically enhances the HbA1c-lowering effect of metformin in vivo. |
| Name | SKI-2852 |
|---|
| Description | A highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively; demonstrates no CYP and PXR liabilities, excellent PK profiles across species, and highly potent and sustainable PD activity; significantly reduces blood glucose and HbA1c levels and improves the lipid profiles in ob/ob mice, synergistically enhances the HbA1c-lowering effect of metformin in vivo. |
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| References | References 1. Ryu JH, et al. J Med Chem. 2016 Nov 23;59(22):10176-10189. View Related Products by Target 11β-HSD |
| Molecular Formula | C27H34FN5O4S |
|---|---|
| Molecular Weight | 543.658 |